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Primarily, it might influence the hormone pathway known as GLP-1, which plays a role in regulating hunger and supporting a balanced metabolism

doi: 10.1007/s10620-013-2775-x 196

The article's reasoning is that these thresholds reflect clinical evidence linking excess weight to cardiovascular and metabolic disease, so the comorbidity is what shifts a borderline BMI into scope

10.1016/j.neuroscience.2012.11.021 Neuroscience 70 HambrightW

Liraglutide treatment also increased endothelial nitric oxide synthase (eNOS) and reduced intercellular adhesion molecule-1 (ICAM-1) expression in the aortic endothelium of atherogenic mice models ApoE / mice model [60]